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The kinetoplastida endocytic apparatus. Part I : a dynamic system for nutrition and evasion of host defences.

Morgan, G. W. and Hall, B. S. and Denny, P. W. and Carrington, M. and Field, M. C. (2002) 'The kinetoplastida endocytic apparatus. Part I : a dynamic system for nutrition and evasion of host defences.', Trends in parasitology., 18 (11). pp. 491-496.


The endocytic system of kinetoplastid parasites is a highly polarized membrane network focused on the flagellar pocket localized at one end of the cell. When first characterized, the endosomal network was envisioned as a simple system for uptake of extracellular material by fluid-phase or receptor-mediated mechanisms. Subsequently, it has become clear that the kinetoplastid endosomal system has an active and vital role in avoiding the host immune system and virulence, as well as providing the basic functions to fulfil cellular nutritional requirements. In two reviews, recent advances in the definition and comprehension of kinetoplastida endocytosis are discussed and, in Trypanosoma brucei in particular as the more developed experimental system. In Part 1, the endocytic system is considered in context of the surface molecules and their potential roles in virulence.

Item Type:Article
Keywords:Blood-stream forms, Trypanosoma-brucei-rhodesiense, Leishmania-infected macrophages, Variant surface glycoprotein, Tumor-necrosis-factor, Transferrin-receptor, African trypanosomes, Density-lipoproteins, Rab11homolog, Lytic factor.
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Record Created:11 May 2009 11:50
Last Modified:09 Jun 2009 15:55

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