SYW Ho
Molecular clocks: when times are a-changin'
Ho, SYW; Larson, G
Authors
G Larson
Abstract
The molecular clock has proved to be extremely valuable in placing timescales on evolutionary events that would otherwise be difficult to date. However, debate has arisen about the considerable disparities between molecular and palaeontological or archaeological dates, and about the remarkably high mutation rates inferred in pedigree studies. We argue that these debates can be largely resolved by reference to the ‘time dependency of molecular rates’, a recent hypothesis positing that short-term mutation rates and long-term substitution rates are related by a monotonic decline from the former to the latter. Accordingly, the extrapolation of rates across different timescales will result in invalid date estimates. We examine the impact of this hypothesis with respect to various fields, including human evolution, animal domestication and conservation genetics. We conclude that many studies involving recent divergence events will need to be reconsidered
Citation
Ho, S., & Larson, G. (2006). Molecular clocks: when times are a-changin'. Trends in Genetics, 22(2), 79-83. https://doi.org/10.1016/j.tig.2005.11.006
Journal Article Type | Article |
---|---|
Publication Date | Feb 1, 2006 |
Deposit Date | Jul 1, 2009 |
Journal | Trends in genetics. |
Print ISSN | 0168-9525 |
Publisher | Cell Press |
Peer Reviewed | Peer Reviewed |
Volume | 22 |
Issue | 2 |
Pages | 79-83 |
DOI | https://doi.org/10.1016/j.tig.2005.11.006 |
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search