M. Sukeik
Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement
Sukeik, M.; Alshryda, S.; Haddad, FS.; Mason, JM.
Authors
S. Alshryda
FS. Haddad
JM. Mason
Abstract
We report a systematic review and meta-analysis of published randomised controlled trials evaluating the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion in total hip replacement (THR). The data were evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group. We identified 11 clinical trials which were suitable for detailed extraction of data. There were no trials that used TXA in revision THR. A total of seven studies (comprising 350 patients) were eligible for the blood loss outcome data. The use of TXA reduced intra-operative blood loss by a mean of 104 ml (95% confidence interval (CI) –164 to –44, p = 0.0006, heterogeneity I2 0%), postoperative blood loss by a mean of 172 ml (95% CI –263 to –81, p = 0.0002, heterogeneity I2 63%) and total blood loss by a mean of 289 ml (95% CI –440 to –138, p < 0.0002, heterogeneity I2 54%). TXA led to a significant reduction in the proportion of patients requiring allogeneic blood transfusion (risk difference –0.20, 95% CI –0.29 to –0.11, p < 0.00001, I2 15%). There were no significant differences in deep-vein thrombosis, pulmonary embolism, infection rates or other complications among the study groups.
Citation
Sukeik, M., Alshryda, S., Haddad, F., & Mason, J. (2011). Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. Journal of bone and joint surgery. British volume, 93-B(1), 39-46. https://doi.org/10.1302/0301-620x.93b1.24984
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2011 |
Deposit Date | Feb 1, 2011 |
Journal | Journal of Bone and Joint Surgery, British Volume |
Print ISSN | 0301-620X |
Publisher | British Editorial Society of Bone and Joint Surgery |
Peer Reviewed | Peer Reviewed |
Volume | 93-B |
Issue | 1 |
Pages | 39-46 |
DOI | https://doi.org/10.1302/0301-620x.93b1.24984 |
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