We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham Research Online
You are in:

Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement.

Sukeik, M. and Alshryda, S. and Haddad, F.S. and Mason, J.F. (2011) 'Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement.', Journal of bone and joint surgery., 93-B (1). pp. 39-46.


We report a systematic review and meta-analysis of published randomised controlled trials evaluating the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion in total hip replacement (THR). The data were evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group. We identified 11 clinical trials which were suitable for detailed extraction of data. There were no trials that used TXA in revision THR. A total of seven studies (comprising 350 patients) were eligible for the blood loss outcome data. The use of TXA reduced intra-operative blood loss by a mean of 104 ml (95% confidence interval (CI) –164 to –44, p = 0.0006, heterogeneity I2 0%), postoperative blood loss by a mean of 172 ml (95% CI –263 to –81, p = 0.0002, heterogeneity I2 63%) and total blood loss by a mean of 289 ml (95% CI –440 to –138, p < 0.0002, heterogeneity I2 54%). TXA led to a significant reduction in the proportion of patients requiring allogeneic blood transfusion (risk difference –0.20, 95% CI –0.29 to –0.11, p < 0.00001, I2 15%). There were no significant differences in deep-vein thrombosis, pulmonary embolism, infection rates or other complications among the study groups.

Item Type:Article
Full text:Full text not available from this repository.
Publisher Web site:
Record Created:01 Feb 2011 12:05
Last Modified:02 Feb 2011 10:44

Social bookmarking: del.icio.usConnoteaBibSonomyCiteULikeFacebookTwitterExport: EndNote, Zotero | BibTex
Look up in GoogleScholar | Find in a UK Library