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The Synthesis of Peptides and Proteins Containing Non-Natural Amino Acids

Hodgson, D.R.W.; Sanderson, J.M.

Authors



Abstract

Methods for the incorporation of non-natural amino acids into proteins have advanced significantly over recent years and in this tutorial review we aim to give a general overview of the area. These techniques offer the possibility of modulating the structures and functions of proteins and thus permit the generation of novel designed systems for both biocatalytic and mechanistic studies. Four complementary approaches are discussed in detail along with examples of their application. The advantages and disadvantages of each technique are also discussed.

Citation

Hodgson, D., & Sanderson, J. (2004). The Synthesis of Peptides and Proteins Containing Non-Natural Amino Acids. Chemical Society Reviews, 33(7), 422-430. https://doi.org/10.1039/b312953p

Journal Article Type Article
Publication Date Aug 1, 2004
Deposit Date Jun 21, 2011
Journal Chemical Society Reviews
Print ISSN 0306-0012
Electronic ISSN 1460-4744
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 33
Issue 7
Pages 422-430
DOI https://doi.org/10.1039/b312953p
Publisher URL http://xlink.rsc.org/?DOI=b312953p