Cookies

We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.


Durham Research Online
You are in:

The facile synthesis of a series of tryptophan derivatives.

Blaser, G. and Sanderson, J. M. and Batsanov, A. S. and Howard, J. A. K. (2008) 'The facile synthesis of a series of tryptophan derivatives.', Tetrahedron letters., 49 (17). pp. 2795-2798.

Abstract

This study reports a facile method for the synthesis of a variety of 5- and 6-substituted tryptophan derivatives that are difficult to prepare using alternative enzymatic approaches. Acylation of an activated amino acid, derived from serine in situ, is coupled with an enzymatic resolution step to furnish enantiopure analogues bearing a range of electron withdrawing and releasing substituents. Isolation of a dehydroalanine derivative as a by-product from some reactions provides some insights into the likely mechanism of the reaction.

Item Type:Article
Full text:PDF - Submitted Version (305Kb)
Status:Not peer-reviewed
Publisher Web site:http://dx.doi.org/10.1016/j.tetlet.2008.02.120
Record Created:21 Jun 2011 15:05
Last Modified:03 Jan 2012 14:22

Social bookmarking: del.icio.usConnoteaBibSonomyCiteULikeFacebookTwitterExport: EndNote, Zotero | BibTex
Usage statisticsLook up in GoogleScholar | Find in a UK Library