DJ Spurgeon
Systems Toxicology Approaches for Understanding the Joint Effects of Environmental Chemical Mixtures
Spurgeon, DJ; Jones, OAH; Dorne, J-L; Svendsen, C.; Swain, S.; Stürzenbaum, S.
Authors
OAH Jones
J-L Dorne
C. Svendsen
S. Swain
S. Stürzenbaum
Abstract
Environmental mixtures of chemicals constitute a prevalent issue in ecotoxicology and the development of new methods to reduce the uncertainties associated with their ecological risk assessment is a critical research need. Historically, a number of models have been explored to predict the potential combined effects of chemicals on species. These models, especially concentration addition and the independent action, have been applied to a number of mixtures. While often providing a good prediction of joint effect, there are cases where these models can have limitations: notably in cases where there are interactions for which they fail to adequately predict joint effects. To support the better mechanistic understanding of interactions in mixture toxicology a framework to support experimental studies to investigate the basis of observed interactions is proposed. The conceptual framework is derived from the extension of a three stage scheme which has previously been applied to understand chemical bioavailability. The framework considers that interactions in mixtures result from processes related to 1) the speciation, binding and transport of chemicals in the exposure medium (external exposure); 2) the adsorption, distribution, metabolism and excretion of chemicals within the organisms (toxicokinetics); 3) associations governing the binding and toxicity of the chemical(s) at the target site (toxicodynamics). The current state of the art in (eco)toxicology in relation to investigation of the mechanisms of interactions between chemicals is discussed with particular emphasis towards the multi-disciplinary tools and techniques within environmental chemistry; toxicology; biochemistry and systems biology that can be used to address such effects.
Citation
Spurgeon, D., Jones, O., Dorne, J., Svendsen, C., Swain, S., & Stürzenbaum, S. (2010). Systems Toxicology Approaches for Understanding the Joint Effects of Environmental Chemical Mixtures. Science of the Total Environment, 408(18), 3725-3734. https://doi.org/10.1016/j.scitotenv.2010.02.038
Journal Article Type | Article |
---|---|
Publication Date | Aug 1, 2010 |
Deposit Date | Sep 8, 2010 |
Journal | Science of the Total Environment |
Print ISSN | 0048-9697 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 408 |
Issue | 18 |
Pages | 3725-3734 |
DOI | https://doi.org/10.1016/j.scitotenv.2010.02.038 |
Keywords | Mixture toxicity, Interaction; External exposure, Toxicokinetics, Toxicodynamics, ‘omics. |
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