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The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels.

Stockman, A. and Smithson, H. E. and Webster, A. R. and Holder, G. E. and Rana, N. A. and Ripamonti, C. and Sharpe, L. T. (2008) 'The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels.', Journal of vision., 8 (1). p. 10.

Abstract

The GTPase activating protein, RGS9-1, is vital for the deactivation and regulation of the phototransduction cascade (C. K. Chen et al., 2000; C. W. Cowan, R. N. Fariss, I. Sokal, K. Palczewski, & T. G. Wensel, 1998; W. He, C. W. Cowan, & T. G. Wensel, 1998; A. L. Lyubarsky et al., 2001). Its loss through genetic defects in humans has been linked to a slow recovery to changes in illumination (K. M. Nishiguchi et al., 2004). Such a deficit is to be expected because RGS9-1 normally speeds up the deactivation of the activated phosphodiesterase effector molecule, PDE6*, and thus accelerates the turning off of the visual response. Paradoxically, however, we find that the cone response in an observer lacking RGS9-1 is faster at lower light levels than it is in a normal observer. Though surprising, this result is nonetheless consistent with molecular models of light adaptation (e.g., E. N. Pugh, S. Nikonov, & T. D. Lamb, 1999), which predict that the excess of PDE6* resulting from the loss of RGS9-1 will shorten the visual integration time and speed up the visual response at inappropriately low light levels. The gain in speed caused by the superfluity of PDE6* at lower light levels compensates for the loss caused by its slow deactivation; thus quickening the response relative to that in the normal. As the light level is increased and the PDE6* concentration in the normal rises relative to that in the observer lacking RGS9-1, the temporal advantage of the latter is soon lost, leaving only the deficit due to delayed deactivation.

Item Type:Article
Keywords:Vision, Cone photoreceptor, Visual transduction, Photopigment,Bradyopsia, RGS9, PDE6, Light adaptation.
Full text:Full text not available from this repository.
Publisher Web site:http://dx.doi.org/10.1167/8.1.10
Record Created:25 Oct 2011 15:20
Last Modified:28 Jun 2012 16:37

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