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Sphingolipid and ceramide homeostasis, potential therapeutic targets.

Young, S.A. and Mina, J.G. and Denny, P.W. and Smith, T.K. (2012) 'Sphingolipid and ceramide homeostasis, potential therapeutic targets.', Biochemistry research international., 2012 . p. 248135.

Abstract

Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.

Item Type:Article
Full text:PDF - Published Version
Available under License Creative Commons Attribution.
(1166Kb)
Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1155/2012/248135
Publisher statement:Copyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Record Created:07 Dec 2011 15:20
Last Modified:10 Feb 2012 15:52

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