S.A. Young
Sphingolipid and ceramide homeostasis, potential therapeutic targets
Young, S.A.; Mina, J.G.; Denny, P.W.; Smith, T.K.
Authors
Dr John Mina j.g.m.mina@durham.ac.uk
Academic Visitor
Professor Paul Denny p.w.denny@durham.ac.uk
Professor
T.K. Smith
Abstract
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.
Citation
Young, S., Mina, J., Denny, P., & Smith, T. (2012). Sphingolipid and ceramide homeostasis, potential therapeutic targets. Biochemistry Research International, 2012, Article 248135. https://doi.org/10.1155/2012/248135
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2012 |
Deposit Date | Oct 21, 2011 |
Publicly Available Date | Mar 29, 2024 |
Journal | Biochemistry Research International |
Print ISSN | 2090-2247 |
Electronic ISSN | 2090-2255 |
Publisher | Hindawi |
Peer Reviewed | Peer Reviewed |
Volume | 2012 |
Article Number | 248135 |
DOI | https://doi.org/10.1155/2012/248135 |
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
Copyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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