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Crystallization of Mefenamic Acid from Dimethylformamide Microemulsions: Obtaining Thermodynamic Control through 3D Nanoconfinement

Nicholson, CE; Cooper, SJ

Crystallization of Mefenamic Acid from Dimethylformamide Microemulsions: Obtaining Thermodynamic Control through 3D Nanoconfinement Thumbnail


Authors

CE Nicholson



Abstract

Recently we showed how crystallization in microemulsions could lead directly to the most stable polymorph, thereby leapfrogging Ostwald’s rule of stages. Here we consider in more details the crystallization of mefenamic acid from dimethylformamide microemulsions. Crystallization of mefenamic acid from bulk DMF has previously been shown to produce only the metastable Form II irrespective of the supersaturation or temperature. In contrast, we show that stable Form I can be produced from DMF microemulsions provided the lowest supersaturations that can achieve crystallization are used; these correspond to initial supersaturations that are significantly higher than those commonly used in bulk solution crystallizations, owing to the large decrease in supersaturation that occurs when a nuclei grows in a 3D-nanoconfined droplet. Increasing the supersaturation above the minimum required for crystallization leads to increasing proportions of metastable Form II crystals. In compositions crystallizing a mixture of Form I and Form II crystals, the Form I crystals can nevertheless be obtained exclusively by slowly heating the microemulsions.

Citation

Nicholson, C., & Cooper, S. (2011). Crystallization of Mefenamic Acid from Dimethylformamide Microemulsions: Obtaining Thermodynamic Control through 3D Nanoconfinement. Crystals, 1(3), 195-205. https://doi.org/10.3390/cryst1030195

Journal Article Type Article
Publication Date Sep 19, 2011
Deposit Date Feb 1, 2012
Publicly Available Date Mar 29, 2024
Journal Crystals
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 1
Issue 3
Pages 195-205
DOI https://doi.org/10.3390/cryst1030195
Keywords Mefenamic acid, Crystallization, Polymorph, Microemulsion, Thermodynamic control.

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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