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Engineering eukaryotic protein factories

Schröder, M.

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Abstract

The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.

Citation

Schröder, M. (2008). Engineering eukaryotic protein factories. Biotechnology Letters, 30(2), 187-196. https://doi.org/10.1007/s10529-007-9524-1

Journal Article Type Article
Publication Date Feb 1, 2008
Deposit Date May 31, 2012
Publicly Available Date Mar 28, 2024
Journal Biotechnology Letters
Print ISSN 0141-5492
Electronic ISSN 1573-6776
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 30
Issue 2
Pages 187-196
DOI https://doi.org/10.1007/s10529-007-9524-1
Keywords Unfolded protein response, Endoplasmic reticulum, Molecular chaperone, Recombinant protein production, Heterologous protein production, Protein folding.

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This article is published under a Creative Commons Attribution (CC-BY) license.





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