A Todd
Targeting the thioredoxin system in the treatment of certain cancers
Todd, A; Anderson, R.J; Pickles, G; Groundwater, P.W
Authors
R.J Anderson
G Pickles
P.W Groundwater
Abstract
The fourth and final science article on cancer treatments reviews the thioredoxin system and its association with cancer, and how it offers a new therapeutic target for anticancer drug design. The most stidied thioredoxin is the classic cytosolic thioredoxin (Trx1), which is the main focus of this article. Two irreversible thioredoxin inhibitors are in development, Px-12 (1-methylpropyl 2-imidazolyl disulphide) and PMX-464 (formerly AW464).
Citation
Todd, A., Anderson, R., Pickles, G., & Groundwater, P. (2010). Targeting the thioredoxin system in the treatment of certain cancers. Pharmaceutical journal (1933), 284, 243-244
| Journal Article Type | Article |
|---|---|
| Publication Date | Mar 1, 2010 |
| Deposit Date | Jun 19, 2012 |
| Journal | Pharmaceutical Journal |
| Print ISSN | 0031-6873 |
| Publisher | Royal Pharmaceutical Society of Great Britain |
| Peer Reviewed | Peer Reviewed |
| Volume | 284 |
| Pages | 243-244 |
| Keywords | Antineoplastics, Breast neoplasms, Drug development, Homeostasis, Gastrointestinal neoplasms, Colorectal neoplasms, Liver neoplasms, Review. |
| Publisher URL | http://www.pjonline.com/series/cancer_treatments |
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