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Rational drug design — identifying and characterising a target

Todd, A; Anderson, R.J; Groundwater, P.W

Authors

A Todd

R.J Anderson

P.W Groundwater



Abstract

Structure-based drug design is now a common method used by the pharmaceutical industry to identify a lead compound and take it forward for further development. This article describes the methods used to identify and characterise a target for structured drug design and illustrates how pharmacists can play an important role in this process, under the headings: identifying a target; proteomics; the poptein databank; DNA; enzyme inhibitors; receptor agonists and antagonists; rational drug design.

Citation

Todd, A., Anderson, R., & Groundwater, P. (2009). Rational drug design — identifying and characterising a target. Pharmaceutical journal (1933), 283(7559), 19-20

Journal Article Type Article
Publication Date Jul 1, 2009
Deposit Date Jun 19, 2012
Journal Pharmaceutical Journal
Print ISSN 0031-6873
Publisher Royal Pharmaceutical Society of Great Britain
Peer Reviewed Peer Reviewed
Volume 283
Issue 7559
Pages 19-20
Keywords Drug Development, Structure-activity Relationship, Proteins, DNA, Enzyme Inhibitors, Review.
Publisher URL http://www.pjonline.com/contents/pj20090704