Todd, A. and Anderson, R.J. and Groundwater, P.W. (2009) 'Rational drug design - identifying and characterising a target.', The pharmaceutical journal., 283 (7559). pp. 19-20.
Structure-based drug design is now a common method used by the pharmaceutical industry to identify a lead compound and take it forward for further development. This article describes the methods used to identify and characterise a target for structured drug design and illustrates how pharmacists can play an important role in this process, under the headings: identifying a target; proteomics; the poptein databank; DNA; enzyme inhibitors; receptor agonists and antagonists; rational drug design.
|Keywords:||Drug Development, Structure-activity Relationship, Proteins, DNA, Enzyme Inhibitors, Review.|
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|Publisher Web site:||http://www.pjonline.com/contents/pj20090704|
|Record Created:||28 Jun 2012 11:20|
|Last Modified:||05 Dec 2012 12:33|
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