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Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum

Lever, C; Burton, S; Jeewajee, A; Wills, TJ; Cacucci, F; Burgess, N; O'Keefe, J

Authors

S Burton

A Jeewajee

TJ Wills

F Cacucci

N Burgess

J O'Keefe



Abstract

The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1.

Citation

Lever, C., Burton, S., Jeewajee, A., Wills, T., Cacucci, F., Burgess, N., & O'Keefe, J. (2010). Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum. Hippocampus, 20(2), 229-234. https://doi.org/10.1002/hipo.20671

Journal Article Type Article
Publication Date Feb 1, 2010
Deposit Date Feb 24, 2012
Journal Hippocampus
Print ISSN 1050-9631
Electronic ISSN 1098-1063
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 20
Issue 2
Pages 229-234
DOI https://doi.org/10.1002/hipo.20671
Keywords Hippocampus, Novelty, Theta, Rhythmic slow activity, Encoding, Retrieval.