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Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum.

Lever, C. and Burton, S. and Jeewajee, A. and Wills, T.J. and Cacucci, F. and Burgess, N. and O'Keefe, J. (2010) 'Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum.', Hippocampus., 20 (2). pp. 229-234.


The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1.

Item Type:Article
Keywords:Hippocampus, Novelty, Theta, Rhythmic slow activity, Encoding, Retrieval.
Full text:Full text not available from this repository.
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Date accepted:No date available
Date deposited:No date available
Date of first online publication:February 2010
Date first made open access:No date available

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