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Anion-switchable supramolecular gels for controlling pharmaceutical crystal growth.

Foster, J.A. and Piepenbrock, M.O.M. and Lloyd, G.O. and Clarke, N. and Howard, J.A.K. and Steed, J.W. (2010) 'Anion-switchable supramolecular gels for controlling pharmaceutical crystal growth.', Nature chemistry., 2 (12). pp. 1037-1043.

Abstract

We describe the use of low-molecular-weight supramolecular gels as media for the growth of molecular crystals. Growth of a range of crystals of organic compounds, including pharmaceuticals, was achieved in bis(urea) gels. Low-molecular-weight supramolecular gelators allow access to an unlimited range of solvent systems, in contrast to conventional aqueous gels such as gelatin and agarose. A detailed study of carbamazepine crystal growth in four different bis(urea) gelators, including a metallogelator, is reported. The crystallization of a range of other drug substances, namely sparfloxacin, piroxicam, theophylline, caffeine, ibuprofen, acetaminophen (paracetamol), sulindac and indomethacin, was also achieved in supramolecular gel media without co-crystal formation. In many cases, crystals can be conveniently recovered from the gels by using supramolecular anion-triggered gel dissolution; however, crystals of substances that themselves bind to anions are dissolved by them. Overall, supramolecular gel-phase crystallization offers an extremely versatile new tool in pharmaceutical polymorph screening.

Item Type:Article
Keywords:Materials chemistry, Supramolecular chemistry.
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1038/nchem.859
Date accepted:No date available
Date deposited:27 March 2013
Date of first online publication:December 2010
Date first made open access:No date available

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