Mechanochemistry: opportunities for new and cleaner synthesis

James, S.L.; Adams, C.J.; Bolm, C.; Braga, D.; Collier, P.; Friščić, T.; Grepioni, F.; Harris, K.D.M.; Hyett, G.; Jones, W.; Krebs, A.; Mack, J.; Maini, L.; Orpen, A.G.; Parkin, I.P.; Shearouse, W.C.; Steed, J.W.; Waddell, D.C.

doi:10.1039/c1cs15171a

Mechanochemistry: opportunities for new and cleaner synthesis

James, S.L.; Adams, C.J.; Bolm, C.; Braga, D.; Collier, P.; Friščić, T.; Grepioni, F.; Harris, K.D.M.; Hyett, G.; Jones, W.; Krebs, A.; Mack, J.; Maini, L.; Orpen, A.G.; Parkin, I.P.; Shearouse, W.C.; Steed, J.W.; Waddell, D.C.

Authors

S.L. James

C.J. Adams

C. Bolm

D. Braga

P. Collier

T. Friščić

F. Grepioni

K.D.M. Harris

G. Hyett

W. Jones

A. Krebs

J. Mack

L. Maini

A.G. Orpen

I.P. Parkin

W.C. Shearouse

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

D.C. Waddell

Abstract

The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).

Citation

James, S., Adams, C., Bolm, C., Braga, D., Collier, P., Friščić, T., …Waddell, D. (2012). Mechanochemistry: opportunities for new and cleaner synthesis. Chemical Society Reviews, 41(1), 413-447. https://doi.org/10.1039/c1cs15171a

Journal Article Type	Article
Publication Date	Jan 1, 2012
Deposit Date	Mar 27, 2013
Publicly Available Date	Mar 27, 2013
Journal	Chemical Society Reviews
Print ISSN	0306-0012
Electronic ISSN	1460-4744
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	41
Issue	1
Pages	413-447
DOI	https://doi.org/10.1039/c1cs15171a