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Mechanochemistry : opportunities for new and cleaner synthesis.

James, S. L. and Adams, C. J. and Bolm, C. and Braga, D. and Collier, P. and Friščić, T. and Grepioni, F. and Harris, K. D. M. and Hyett, G. and Jones, W. and Krebs, A. and Mack, J. and Maini, L. and Orpen, A. G. and Parkin, I. P. and Shearouse, W. C. and Steed, J. W. and Waddell, D. C. (2012) 'Mechanochemistry : opportunities for new and cleaner synthesis.', Chemical society reviews., 41 (1). pp. 413-447.


The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).

Item Type:Article
Full text:(AM) Accepted Manuscript
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Date accepted:No date available
Date deposited:27 March 2013
Date of first online publication:2012
Date first made open access:No date available

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