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Unexpected low temperature behaviour of piroxicam monohydrate.

Fucke, K. and Edwards, A. J. and Probert, M. R. and Tallentire, S. E. and Howard, J. A. K. and Steed, J. W. (2013) 'Unexpected low temperature behaviour of piroxicam monohydrate.', ChemPhysChem., 14 (4). pp. 675-679.


Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other.

Item Type:Article
Keywords:Lattice energy calculations, Neutron diffraction, Piroxicam monohydrate, Temperature-controlled analysis, X-ray diffraction.
Full text:(AM) Accepted Manuscript
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Publisher statement:This is the peer reviewed version of the following article: Fucke, K., Edwards, A. J., Probert, M. R., Tallentire, S. E., Howard, J. A. K. and Steed, J. W. (2013), Unexpected Low-Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14 (4): 675–679, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Date accepted:No date available
Date deposited:27 March 2013
Date of first online publication:March 2013
Date first made open access:No date available

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