We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham Research Online
You are in:

The role of co-crystals in pharmaceutical design.

Steed, J. W. (2013) 'The role of co-crystals in pharmaceutical design.', Trends in pharmacological sciences., 34 (3). pp. 185-193.


Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation and characterisation, and implications for regulatory control and intellectual property (IP) protection. Concepts are illustrated with highly selected examples of pharmaceutical co-crystal systems within the wider context of crystal engineering and research in molecular solids.

Item Type:Article
Keywords:Solid form, Polymorph, Solubility, Formulation, Solvate.
Full text:(AM) Accepted Manuscript
Download PDF
Publisher Web site:
Publisher statement:NOTICE: this is the author’s version of a work that was accepted for publication in Trends in pharmacological sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in pharmacological sciences, 34 (3), March 2013, 10.1016/
Date accepted:No date available
Date deposited:24 April 2013
Date of first online publication:2013
Date first made open access:No date available

Save or Share this output

Look up in GoogleScholar