Steed, J. W. (2013) 'The role of co-crystals in pharmaceutical design.', Trends in pharmacological sciences., 34 (3). pp. 185-193.
Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation and characterisation, and implications for regulatory control and intellectual property (IP) protection. Concepts are illustrated with highly selected examples of pharmaceutical co-crystal systems within the wider context of crystal engineering and research in molecular solids.
|Keywords:||Solid form, Polymorph, Solubility, Formulation, Solvate.|
|Full text:||(AM) Accepted Manuscript|
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|Publisher Web site:||https://doi.org/10.1016/j.tips.2012.12.003|
|Publisher statement:||NOTICE: this is the author’s version of a work that was accepted for publication in Trends in pharmacological sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in pharmacological sciences, 34 (3), March 2013, 10.1016/j.tips.2012.12.003|
|Date accepted:||No date available|
|Date deposited:||24 April 2013|
|Date of first online publication:||2013|
|Date first made open access:||No date available|
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