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A specific role for septohippocampal acetylcholine in memory?

Easton, A. and Douchamps, V. and Eacott, M.J. and Lever, C. (2012) 'A specific role for septohippocampal acetylcholine in memory?', Neuropsychologia., 50 (13). pp. 3156-3168.


Acetylcholine has long been implicated in memory, including hippocampal-dependent memory, but the specific role for this neurotransmitter is difficult to identify in human neuropsychology. Here, we review the evidence for a mechanistic model of acetylcholine function within the hippocampus and consider its explanatory power for interpreting effects resulting from both pharmacological anticholinergic manipulations and lesions of the cholinergic input to the hippocampus in animals. We argue that these effects indicate that acetylcholine is necessary for some, but not all, hippocampal-dependent processes. We review recent evidence from lesion, pharmacological and electrophysiological studies to support the view that a primary function of septohippocampal acetylcholine is to reduce interference in the learning process by adaptively timing and separating encoding and retrieval processes. We reinterpret cholinergic-lesion based deficits according to this view and propose that acetylcholine reduces the interference elicited by the movement of salient locations between events.

Item Type:Article
Keywords:Oscillations, Theta, Scopolamine, Rats, Episodic memory, Spatial memory.
Full text:(AM) Accepted Manuscript
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Available under License - Creative Commons Attribution.
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Publisher statement:© 2012 Elsevier Ltd. Article available under open access licence CC-BY.
Date accepted:No date available
Date deposited:05 July 2013
Date of first online publication:2012
Date first made open access:No date available

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