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Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart

Shenton, F.C.; Pyner, S.

Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart Thumbnail


Authors

F.C. Shenton



Abstract

The atrial volume receptor reflex arc serves to regulate plasma volume. Atrial volume receptors located in the endocardium of the atrial wall undergo mechanical deformation as blood is returned to the atria of the heart. The mechanosensitive channel(s) responsible for regulating plasma volume remain to be determined. Here we report that the TRP channel family members TRPC1 and TRPV4 were expressed in sensory nerve endings in the atrial endocardium. Furthermore, TRPC1 and TRPV4 were coincident with the nerve ending vesicle marker synaptophysin. Calcitonin gene-related peptide was exclusively confined to the myo- and epicardium of the atria. The small conductance Ca2+-activated K+ channels (SK2 and SK4) were also present, however there was no relationship between SK and TRP channels. SK2 channels were expressed in nerves in the epicardium, while SK4 channels were in some regions of the endocardium but appeared to be present in epithelial cells rather than sensory endings. In conclusion, we have provided the first evidence for TRPC1 and TRPV4 channels as potential contributors to mechanosensation in the atrial volume receptors.

Citation

Shenton, F., & Pyner, S. (2014). Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart. Neuroscience, 267, 195-204. https://doi.org/10.1016/j.neuroscience.2014.02.047

Journal Article Type Article
Acceptance Date Feb 27, 2014
Online Publication Date Mar 11, 2014
Publication Date May 16, 2014
Deposit Date Feb 27, 2014
Publicly Available Date Mar 28, 2024
Journal Neuroscience
Print ISSN 0306-4522
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 267
Pages 195-204
DOI https://doi.org/10.1016/j.neuroscience.2014.02.047
Keywords TRPC1, TRPV4, Synaptophysin, Atrial volume receptor, Mechanosensation, SK channels.

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