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Investigating the micro-rheology of the vitreous humor using an optically trapped local probe.

Watts, Fiona and Tan, Lay Ean and Wilson, Clive G. and Girkin, John M. and Tassieri, Manlio and Wright, Amanda Jane (2014) 'Investigating the micro-rheology of the vitreous humor using an optically trapped local probe.', Journal of optics., 16 (1). 015301.


We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

Item Type:Article
Keywords:Optical trapping, Micro-rheology, Vitreous humor.
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Publisher statement:Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Date accepted:No date available
Date deposited:26 May 2014
Date of first online publication:January 2014
Date first made open access:No date available

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