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From structure to function : mitochondrial morphology, motion and shaping in vascular smooth muscle.

McCarron, John G. and Wilson, Calum and Sandison, Mairi E. and Olson, Marnie L. and Girkin, John M. and Saunter, Christopher and Chalmers, Susan (2013) 'From structure to function : mitochondrial morphology, motion and shaping in vascular smooth muscle.', Journal of vascular research., 50 (5). pp. 357-371.

Abstract

The diversity of mitochondrial arrangements, which arise from the organelle being static or moving, or fusing and dividing in a dynamically reshaping network, is only beginning to be appreciated. While significant progress has been made in understanding the proteins that reorganise mitochondria, the physiological significance of the various arrangements is poorly understood. The lack of understanding may occur partly because mitochondrial morphology is studied most often in cultured cells. The simple anatomy of cultured cells presents an attractive model for visualizing mitochondrial behaviour but contrasts with the complexity of native cells in which elaborate mitochondrial movements and morphologies may not occur. Mitochondrial changes may take place in native cells (in response to stress and proliferation), but over a slow time-course and the cellular function contributed is unclear. To determine the role mitochondrial arrangements play in cell function, a crucial first step is characterisation of the interactions among mitochondrial components. Three aspects of mitochondrial behaviour are described in this review: (1) morphology, (2) motion and (3) rapid shape changes. The proposed physiological roles to which various mitochondrial arrangements contribute and difficulties in interpreting some of the physiological conclusions are also outlined.

Item Type:Article
Keywords:Mitochondrial dynamics, Smooth muscle proliferation, Mitochondrial fission, Mitochondrial fusion.
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1159/000353883
Publisher statement:This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0) (www.karger.com/OA-license-WT), applicable to the online version of the article only.
Date accepted:No date available
Date deposited:02 June 2014
Date of first online publication:October 2013
Date first made open access:No date available

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