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Bivariate estimation of distribution algorithms for protein structure prediction.

Bonetti, Daniel and Delbem, Alexandre and Einbeck, Jochen (2014) 'Bivariate estimation of distribution algorithms for protein structure prediction.', in 29th International Workshop on Statistical Modelling, 14-18 July 2014, Göttingen, Germany ; proceedings. Amsterdam: Statistical Modelling Society, pp. 15-18.


A real-valued bivariate ‘Estimation of Distribution Algorithm’ specific for the ab initio and full-atom Protein Structure Prediction problem is proposed. It is known that this is a multidimensional and multimodal problem. In order to deal with the multimodality and the correlation of dihedral angles φ and ψ, we developed approaches based on Kernel Density Estimation and Finite Gaussian Mixtures. Simulation results have shown that both techniques are promising when applied to that problem.

Item Type:Book chapter
Full text:(AM) Accepted Manuscript
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Date accepted:No date available
Date deposited:06 October 2014
Date of first online publication:2014
Date first made open access:No date available

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