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Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder.

Najt, P. and Hausmann, M. (2014) 'Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder.', Psychiatry research., 220 (1-2). pp. 315-321.

Abstract

Bipolar disorder (BD) has been associated with right hemisphere dysfunction. These findings usually come from studies that have not distinguished between symptomatic and euthymic states of BD. The present study aims to investigate atypical right (and left) hemispheric functioning in euthymic BD patients. We evaluated 40 participants (18 healthy controls and 22 euthymic BD patients) using an emotional prosody dichotic listening task and a linguistic dichotic listening task which have been shown to produce a strong left ear advantage (LEA) and right ear advantage (REA), indicating a right and left hemisphere superiority, respectively. The results replicate the well-known LEA in emotional prosody for healthy controls. In contrast, no ear advantage was found for emotional prosody in euthymic BD patients. Both groups revealed the well-established REA in the linguistic dichotic listening task. The patient group was heterogeneous with regard to medication, as it consisted of patients with a variety of pharmacological treatments. The results are in line with previous studies in symptomatic BD patients, and suggest that atypical LEA in emotional prosody can be interpreted as a neurobehavioral vulnerability marker of emotional dysregulation and dysfunction in the right hemispheric fronto-temporal network in both symptomatic and euthymic BD patients.

Item Type:Article
Keywords:Dichotic listening, Functional hemispheric asymmetries, Emotional prosody, Emotion regulation, Euthymia.
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1016/j.psychres.2014.08.015
Publisher statement:NOTICE: this is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research, 220, 1-2, 15 December 2014, 10.1016/j.psychres.2014.08.015.
Date accepted:08 July 2013
Date deposited:18 November 2014
Date of first online publication:December 2014
Date first made open access:No date available

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