Butler, S.J. and Delbianco, M. and Lamarque, L. and McMahon, B.K. and Neil, E.R. and Pal, R. and Parker, D. and Walton, J.W. and Zwier, J. (2015) 'EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.', Dalton transactions., 44 (11). pp. 4791-4803.
The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time-resolved FRET methods.
|Full text:||(AM) Accepted Manuscript|
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|Publisher Web site:||http://dx.doi.org/10.1039/C4DT02785J|
|Date accepted:||10 October 2014|
|Date deposited:||20 November 2014|
|Date of first online publication:||13 October 2014|
|Date first made open access:||No date available|
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