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EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.

Butler, S.J. and Delbianco, M. and Lamarque, L. and McMahon, B.K. and Neil, E.R. and Pal, R. and Parker, D. and Walton, J.W. and Zwier, J. (2015) 'EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.', Dalton transactions., 44 (11). pp. 4791-4803.

Abstract

The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time-resolved FRET methods.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1039/C4DT02785J
Date accepted:10 October 2014
Date deposited:20 November 2014
Date of first online publication:13 October 2014
Date first made open access:No date available

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