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Hippocampal synaptic plasticity, spatial memory and anxiety.

Bannerman, D.M. and Sprengel, R. and Sanderson, D.J. and McHugh, S.B. and Rawlins, J.N.P. and Monyer, H. and Seeburg, P.H. (2014) 'Hippocampal synaptic plasticity, spatial memory and anxiety.', Nature reviews neuroscience., 15 (3). pp. 181-192.


Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Item Type:Article
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Date accepted:No date available
Date deposited:19 December 2014
Date of first online publication:20 February 2014
Date first made open access:No date available

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