Solid-state NMR studies of nucleic acid components

Dračínský, Martin; Hodgkinson, Paul

doi:10.1039/c4ra14404j

Solid-state NMR studies of nucleic acid components

Dračínský, Martin; Hodgkinson, Paul

Authors

Martin Dračínský

Professor Paul Hodgkinson paul.hodgkinson@durham.ac.uk
Professor

Abstract

Recent applications of solid-state NMR to the characterisation of nucleic acid systems are reviewed. Developments in NMR methodology and DFT-based first-principles calculations have led to the emergence of “NMR crystallography”, where solid-state NMR provides information on local structure and dynamics that complements information on periodic ordering and overall structure provided by traditional diffraction crystallography. The solid-state NMR is shown to provide direct information on hydrogen-bonding arrangements, metal ion interactions and local molecular dynamics that is difficult to obtain by other techniques, including solution-state NMR.

Citation

Dračínský, M., & Hodgkinson, P. (2015). Solid-state NMR studies of nucleic acid components. RSC Advances, 5(16), 12300-12310. https://doi.org/10.1039/c4ra14404j

Journal Article Type	Article
Publication Date	Jan 9, 2015
Deposit Date	Jan 23, 2015
Publicly Available Date	Jan 30, 2015
Journal	RSC Advances
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	5
Issue	16
Pages	12300-12310
DOI	https://doi.org/10.1039/c4ra14404j