Lowery, R. and Gibson, M.I. and Thompson, R.L. and Fullam, E. (2015) 'Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis.', Chemical communications., 51 (23). pp. 4838-4841.
Abstract
Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.
| Item Type: | Article |
|---|---|
| Full text: | (AM) Accepted Manuscript Download PDF (474Kb) |
| Full text: | (VoR) Version of Record Available under License - Creative Commons Attribution. Download PDF (1789Kb) |
| Status: | Peer-reviewed |
| Publisher Web site: | http://dx.doi.org/10.1039/C4CC09588J |
| Publisher statement: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| Date accepted: | 12 February 2015 |
| Date deposited: | 24 February 2015 |
| Date of first online publication: | March 2015 |
| Date first made open access: | No date available |
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