Lowery, R. and Gibson, M.I. and Thompson, R.L. and Fullam, E. (2015) 'Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis.', Chemical communications., 51 (23). pp. 4838-4841.
Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.
|Full text:||(AM) Accepted Manuscript|
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|Publisher Web site:||http://dx.doi.org/10.1039/C4CC09588J|
|Publisher statement:||This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.|
|Date accepted:||12 February 2015|
|Date deposited:||24 February 2015|
|Date of first online publication:||March 2015|
|Date first made open access:||No date available|
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