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A procedure for the preparation and isolation of nucleoside-5’-diphosphates

Korhonen, H.J.; Bolt, H.L.; Hodgson, D.R.W.

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Authors

H.J. Korhonen

H.L. Bolt



Abstract

Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5’-diphosphates from crude reaction mixtures.

Citation

Korhonen, H., Bolt, H., & Hodgson, D. (2015). A procedure for the preparation and isolation of nucleoside-5’-diphosphates. Beilstein Journal of Organic Chemistry, 11, 469-472. https://doi.org/10.3762/bjoc.11.52

Journal Article Type Article
Acceptance Date Mar 25, 2015
Publication Date Apr 10, 2015
Deposit Date Apr 8, 2015
Publicly Available Date Mar 29, 2024
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 11
Pages 469-472
DOI https://doi.org/10.3762/bjoc.11.52
Keywords NDP synthesis, Nucleic acids, Nucleoside-5’-diphosphate, Phosphorylation.

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