Sadler, S. A. and Hones, A. C. and Roberts, B. and Blakemore, D.C. and Marder, T. B. and Steel, P.G. (2015) 'Multidirectional synthesis of substituted indazoles via iridium-catalyzed C-H borylation.', Journal of organic chemistry., 80 (10). pp. 5308-5314.
Abstract
In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C–H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.
| Item Type: | Article |
|---|---|
| Full text: | (AM) Accepted Manuscript Download PDF (810Kb) |
| Status: | Peer-reviewed |
| Publisher Web site: | http://dx.doi.org/10.1021/acs.joc.5b00452 |
| Publisher statement: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © 2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.joc.5b00452. |
| Date accepted: | 12 May 2015 |
| Date deposited: | 26 May 2015 |
| Date of first online publication: | May 2015 |
| Date first made open access: | 01 May 2016 |
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