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Multidirectional synthesis of substituted indazoles via iridium-catalyzed C-H borylation.

Sadler, S. A. and Hones, A. C. and Roberts, B. and Blakemore, D.C. and Marder, T. B. and Steel, P.G. (2015) 'Multidirectional synthesis of substituted indazoles via iridium-catalyzed C-H borylation.', Journal of organic chemistry., 80 (10). pp. 5308-5314.


In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C–H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © 2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Date accepted:12 May 2015
Date deposited:26 May 2015
Date of first online publication:May 2015
Date first made open access:01 May 2016

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