The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Roper, Kimberley A.; Lange, Heiko; Polyzos, Anastasios; Berry, Malcolm B.; Baxendale, Ian R.; Ley, Steven V.

doi:10.3762/bjoc.7.194

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Roper, Kimberley A.; Lange, Heiko; Polyzos, Anastasios; Berry, Malcolm B.; Baxendale, Ian R.; Ley, Steven V.

Authors

Kimberley A. Roper

Heiko Lange

Anastasios Polyzos

Malcolm B. Berry

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Steven V. Ley

Abstract

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

Citation

Roper, K. A., Lange, H., Polyzos, A., Berry, M. B., Baxendale, I. R., & Ley, S. V. (2011). The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors. Beilstein Journal of Organic Chemistry, 7, 1648-1655. https://doi.org/10.3762/bjoc.7.194

Journal Article Type	Article
Acceptance Date	Nov 16, 2011
Publication Date	Dec 8, 2011
Deposit Date	Jul 14, 2014
Publicly Available Date	Jun 1, 2015
Journal	Beilstein Journal of Organic Chemistry
Print ISSN	1860-5397
Publisher	Beilstein-Institut
Peer Reviewed	Peer Reviewed
Volume	7
Pages	1648-1655
DOI	https://doi.org/10.3762/bjoc.7.194
Keywords	Appel reaction, Bromination, Flow chemistry, Solid-supported reagent; triphenylphosphine monolith

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Copyright Statement
© 2011 Baumann et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)