The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I.R.

doi:10.3762/bjoc.11.134

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Baumann, M.; Baxendale, I.R.

Authors

M. Baumann

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.

Citation

Baumann, M., & Baxendale, I. (2015). The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry. Beilstein Journal of Organic Chemistry, 2015(11), 1194-1219. https://doi.org/10.3762/bjoc.11.134

Journal Article Type	Article
Acceptance Date	Apr 28, 2015
Publication Date	Jul 17, 2015
Deposit Date	May 4, 2015
Publicly Available Date	Aug 7, 2015
Journal	Beilstein Journal of Organic Chemistry
Print ISSN	1860-5397
Publisher	Beilstein-Institut
Peer Reviewed	Peer Reviewed
Volume	2015
Issue	11
Pages	1194-1219
DOI	https://doi.org/10.3762/bjoc.11.134
Keywords	Continuous processing, Flow synthesis, In-line analysis, Manufacture, Pharmaceuticals, Scalability.

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Copyright Statement
© 2015 Baumann and Baxendale; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.