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Approaching ‘kit-type’ labelling with 68Ga : the DATA chelators.

Seemann, J. and Waldron, B.P. and Roesch, F. and Parker, D. (2015) 'Approaching ‘kit-type’ labelling with 68Ga : the DATA chelators.', ChemMedChem., 10 (6). pp. 1019-1026.

Abstract

The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators—DATAM, DATAP, DATAPh, and DATAPPh—with 68Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using 68Ga positron emission tomography (PET).

Item Type:Article
Keywords:Chelates, Gallium-68, Ligand design, Macrocyclic ligands, Radiopharmaceuticals.
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1002/cmdc.201500092
Publisher statement:This is the peer reviewed version of the following article: FSeemann, J., Waldron, B. P., Roesch, F. and Parker, D. (2015), Approaching ‘Kit-Type’ Labelling with 68Ga: The DATA Chelators. ChemMedChem, 10(6): 1019-1026, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201500092. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.
Date accepted:No date available
Date deposited:27 July 2015
Date of first online publication:21 April 2015
Date first made open access:21 April 2016

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