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Supramolecular Gel Control of Cisplatin Crystallization: Identification of a New Solvate Form Using a Cisplatin-Mimetic Gelator

Dawn, Arnab; Andrew, Katherine S.; Yufit, Dmitry S.; Hong, Yuexian; Reddy, J. Prakasha; Jones, Christopher D.; Aguilar, Juan A.; Steed, Jonathan W.

Supramolecular Gel Control of Cisplatin Crystallization: Identification of a New Solvate Form Using a Cisplatin-Mimetic Gelator Thumbnail


Authors

Arnab Dawn

Katherine S. Andrew

Dmitry S. Yufit

Yuexian Hong

J. Prakasha Reddy

Christopher D. Jones

Juan A. Aguilar



Abstract

A series of platinum based low-molecular-weight urea-based gelators C1, C2, and C3, mimicking the structure of the anticancer drug cisplatin has been synthesized, as part of the development of a targeted, supramolecular gel phase crystallization and polymorphism screening strategy. Morphological and rheological studies established that inclusion of a longer spacer between the urea and cisplatin-mimetic regions of the gelator (C3) resulted in optimal gelation performance. Interfacial crystallization of cisplatin in a gel–sol biphasic system has been employed to address the insolubility of the drug molecule in organic solvents. A new N,N-dimethylacetamide (DMA) solvate of cisplatin has been identified and a crystal habit modification of the known N,N-dimethylformamide (DMF) solvate form of cisplatin has been observed on crystallization of cisplatin in C3 gels prepared in xylenes. While both targeted and nontargeted gels resulted in the formation of the new DMA solvate, only the targeted C3 gel resulted in high-quality single crystal suitable for characterization by single crystal crystallography. The high crystal quality is attributed to a close match between the core geometry of C3 with that of cisplatin together with local order in the gel fibers of C3.

Citation

Dawn, A., Andrew, K. S., Yufit, D. S., Hong, Y., Reddy, J. P., Jones, C. D., …Steed, J. W. (2015). Supramolecular Gel Control of Cisplatin Crystallization: Identification of a New Solvate Form Using a Cisplatin-Mimetic Gelator. Crystal Growth and Design, 15(9), 4591-4599. https://doi.org/10.1021/acs.cgd.5b00840

Journal Article Type Article
Acceptance Date Aug 10, 2015
Publication Date Sep 2, 2015
Deposit Date Oct 2, 2015
Publicly Available Date Mar 28, 2024
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 15
Issue 9
Pages 4591-4599
DOI https://doi.org/10.1021/acs.cgd.5b00840

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © 2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.5b00840.





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