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Supramolecular gel control of cisplatin crystallization : identification of a new solvate form using a cisplatin-mimetic gelator.

Dawn, Arnab and Andrew, Katherine S. and Yufit, Dmitry S. and Hong, Yuexian and Reddy, J. Prakasha and Jones, Christopher D. and Aguilar, Juan A. and Steed, Jonathan W. (2015) 'Supramolecular gel control of cisplatin crystallization : identification of a new solvate form using a cisplatin-mimetic gelator.', Crystal growth & design., 15 (9). pp. 4591-4599.


A series of platinum based low-molecular-weight urea-based gelators C1, C2, and C3, mimicking the structure of the anticancer drug cisplatin has been synthesized, as part of the development of a targeted, supramolecular gel phase crystallization and polymorphism screening strategy. Morphological and rheological studies established that inclusion of a longer spacer between the urea and cisplatin-mimetic regions of the gelator (C3) resulted in optimal gelation performance. Interfacial crystallization of cisplatin in a gel–sol biphasic system has been employed to address the insolubility of the drug molecule in organic solvents. A new N,N-dimethylacetamide (DMA) solvate of cisplatin has been identified and a crystal habit modification of the known N,N-dimethylformamide (DMF) solvate form of cisplatin has been observed on crystallization of cisplatin in C3 gels prepared in xylenes. While both targeted and nontargeted gels resulted in the formation of the new DMA solvate, only the targeted C3 gel resulted in high-quality single crystal suitable for characterization by single crystal crystallography. The high crystal quality is attributed to a close match between the core geometry of C3 with that of cisplatin together with local order in the gel fibers of C3.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © 2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Date accepted:10 August 2015
Date deposited:06 October 2015
Date of first online publication:September 2015
Date first made open access:18 August 2016

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