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Durham Research Online
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Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers.

Johnson, D.W. and Langford, C.R. and Didsbury, M.P. and Lipp, B. and Przyborski, S.A. and Cameron, N.R. (2015) 'Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers.', Polymer chemistry., 6 (41). pp. 7256-7263.

Abstract

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materials have nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblast cells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1039/C5PY00721F
Date accepted:08 June 2015
Date deposited:18 January 2016
Date of first online publication:09 June 2015
Date first made open access:08 June 2016

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