Moseley, Peter and Alderson-Day, Ben and Ellison, Amanda and Jardri, Renaud and Fernyhough, Charles (2016) 'Non-invasive brain stimulation and auditory verbal hallucinations : new techniques and future directions.', Frontiers in neuroscience., 9 . p. 515.
Auditory verbal hallucinations (AVHs) are the experience of hearing a voice in the absence of any speaker. Results from recent attempts to treat AVHs with neurostimulation (rTMS or tDCS) to the left temporoparietal junction have not been conclusive, but suggest that it may be a promising treatment option for some individuals. Some evidence suggests that the therapeutic effect of neurostimulation on AVHs may result from modulation of cortical areas involved in the ability to monitor the source of self-generated information. Here, we provide a brief overview of cognitive models and neurostimulation paradigms associated with treatment of AVHs, and discuss techniques that could be explored in the future to improve the efficacy of treatment, including alternating current and random noise stimulation. Technical issues surrounding the use of neurostimulation as a treatment option are discussed (including methods to localize the targeted cortical area, and the state-dependent effects of brain stimulation), as are issues surrounding the acceptability of neurostimulation for adolescent populations and individuals who experience qualitatively different types of AVH.
|Keywords:||Hallucinations, Neurostimulation, Neuronavigation, State dependency, Transcranial random noise stimulation (tRNS), Transcranial direct current stimulation (tDCS), Transcranial alternating current stimulation (tACS), Transcranial magnetic stimulation (TMS)|
|Full text:||(VoR) Version of Record|
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|Publisher Web site:||https://doi.org/10.3389/fnins.2015.00515|
|Publisher statement:||© 2016 Moseley, Alderson-Day, Ellison, Jardri and Fernyhough. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.|
|Date accepted:||22 December 2015|
|Date deposited:||26 January 2016|
|Date of first online publication:||19 January 2016|
|Date first made open access:||26 January 2016|
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