An Arabidopsis gene regulatory network for secondary cell wall synthesis

Taylor-Teeples, M.; Lin, L.; de Lucas, M.; Turco, G.; Toal, T.W.; Gaudinier, A.; Young, N.F.; Trabucco, G.M.; Veling, M.T.; Lamothe, R.; Handakumbura, P.P.; Xiong, G.; Wang, C.; Corwin, J.; Tsoukalas, A.; Zhang, L.; Ware, D.; Pauly, M.; Kliebenstein, D.J.; Dehesh, K.; Tagkopoulos, I.; Breton, G.; Pruneda-Paz, J.L.; Ahnert, S.E.; Kay, S.A.; Hazen, S.P.; Brady, S.M.

doi:10.1038/nature14099

An Arabidopsis gene regulatory network for secondary cell wall synthesis

Taylor-Teeples, M.; Lin, L.; de Lucas, M.; Turco, G.; Toal, T.W.; Gaudinier, A.; Young, N.F.; Trabucco, G.M.; Veling, M.T.; Lamothe, R.; Handakumbura, P.P.; Xiong, G.; Wang, C.; Corwin, J.; Tsoukalas, A.; Zhang, L.; Ware, D.; Pauly, M.; Kliebenstein, D.J.; Dehesh, K.; Tagkopoulos, I.; Breton, G.; Pruneda-Paz, J.L.; Ahnert, S.E.; Kay, S.A.; Hazen, S.P.; Brady, S.M.

Authors

M. Taylor-Teeples

L. Lin

Dr Miguel De Lucas Torres miguel.de-lucas@durham.ac.uk
Associate Professor

G. Turco

T.W. Toal

A. Gaudinier

N.F. Young

G.M. Trabucco

M.T. Veling

R. Lamothe

P.P. Handakumbura

G. Xiong

C. Wang

J. Corwin

A. Tsoukalas

L. Zhang

D. Ware

M. Pauly

D.J. Kliebenstein

K. Dehesh

I. Tagkopoulos

G. Breton

J.L. Pruneda-Paz

S.E. Ahnert

S.A. Kay

S.P. Hazen

S.M. Brady

Abstract

The plant cell wall is an important factor for determining cell shape, function and response to the environment. Secondary cell walls, such as those found in xylem, are composed of cellulose, hemicelluloses and lignin and account for the bulk of plant biomass. The coordination between transcriptional regulation of synthesis for each polymer is complex and vital to cell function. A regulatory hierarchy of developmental switches has been proposed, although the full complement of regulators remains unknown. Here we present a protein–DNA network between Arabidopsis thaliana transcription factors and secondary cell wall metabolic genes with gene expression regulated by a series of feed-forward loops. This model allowed us to develop and validate new hypotheses about secondary wall gene regulation under abiotic stress. Distinct stresses are able to perturb targeted genes to potentially promote functional adaptation. These interactions will serve as a foundation for understanding the regulation of a complex, integral plant component.

Citation

Taylor-Teeples, M., Lin, L., de Lucas, M., Turco, G., Toal, T., Gaudinier, A., …Brady, S. (2014). An Arabidopsis gene regulatory network for secondary cell wall synthesis. Nature, 517(7536), 571-575. https://doi.org/10.1038/nature14099

Journal Article Type	Article
Acceptance Date	Nov 20, 2014
Online Publication Date	Dec 24, 2014
Publication Date	Dec 24, 2014
Deposit Date	Nov 11, 2015
Publicly Available Date	Mar 18, 2016
Journal	Nature
Print ISSN	0028-0836
Electronic ISSN	1476-4687
Publisher	Nature Research
Peer Reviewed	Peer Reviewed
Volume	517
Issue	7536
Pages	571-575
DOI	https://doi.org/10.1038/nature14099