Hot flushes and reproductive hormone levels during the menopausal transition.

Abstract

Introduction Evidence suggests that hot flushes are associated with fluctuating levels of oestradiol (E2) during menop\\10.10.23.91\S5_WatchFolder\REJECTED\MNT_ELSEVIER_JOURNAL_MAT_6582_110ause, as well as changes in the levels of follicle-stimulating hormone (FSH) and inhibin B. The relationship between hot flushes and anti-Müllerian hormone (AMH) is unknown. Aim To examine specific hormone levels and ethnic differences in relation to hot flushes. Methods Data were drawn from 108 women aged 40–59 years. There were three groups of participants: European women in London, UK; Bangladeshi women in Sylhet, Bangladesh; and Bangladeshi women who had migrated to London as adults. Symptom information was collected via questionnaires. Serum blood samples were collected to detect inhibin B, AMH, FSH, and E2. Results AMH and FSH were significantly associated with the experience of hot flushes in the past 2 weeks. Inhibin B and E2 were not associated with hot flushes. Body mass index (BMI), ethnicity, and education level were associated with both the occurrence and the frequency hot flushes. Menopausal status was also associated with the frequency of hot flushes. Conclusion Relationships between AMH, FSH and symptoms are indicative of women’s progress through the menopausal transition. The influence of BMI and education suggest that lifestyle changes may contribute to the management of symptoms. This merits further research.