Garrison, J. and Fernyhough, C. and McCarthy-Jones, S. and Haggard, M. and The Australian Schizophrenia Research Bank, and Simons, J. S. (2015) 'Paracingulate sulcus morphology is associated with hallucinations in the human brain.', Nature communications., 6 . p. 8956.
Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1 cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.
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|Publisher Web site:||http://dx.doi.org/10.1038/ncomms9956|
|Publisher statement:||This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/|
|Date accepted:||19 October 2015|
|Date deposited:||07 April 2016|
|Date of first online publication:||17 November 2015|
|Date first made open access:||No date available|
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