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Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals.

Kaufmann, Lena and Kennedy, Stuart R. and Jones, Christopher D. and Steed, Jonathan W. (2016) 'Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals.', Chemical communications., 52 (66). pp. 10113-10116.

Abstract

We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks. Gels are formed by a calixarene based tetrahydrazide gelator or a co-gel of a calixarene diammonium salt and a bis-crown ether. The calixarene hydrophobic cavity enables the complexation of hydrophobic drug molecules in a generic fashion thus providing an anchor site on the surface of the gel fibre to inititate drug crystal nucleation and growth. This technique potentially represents a route to growth of hard-to-nucleate polymorphic modifications. The co-gel comprising two components holding together by non-covalent ammonium-crown ether interaction can be easily switched back to the sol state by adding competitive binding cations.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1039/C6CC04037C
Publisher statement:This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Date accepted:29 June 2016
Date deposited:30 June 2016
Date of first online publication:29 June 2016
Date first made open access:No date available

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