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Expanding the pyridine–formic acid cocrystal landscape under extreme conditions.

Lee, Rachael and Firbank, Andrew J. and Probert, Michael R. and Steed, Jonathan W. (2016) 'Expanding the pyridine–formic acid cocrystal landscape under extreme conditions.', Crystal growth & design., 16 (7). pp. 4005-4011.


Pyridine and formic acid have been crystallized at differing ratios by both cryocrystallization and compression in a diamond anvil cell. Mixtures of the liquids in 1:1, 1:2, and 1:4 ratios all crystallize at high pressure, while only the 1:1 and 1:4 compositions were crystallized by in situ low temperature capillary crystallization. The 1:2 structure crystallized by high pressure is a previously unknown cocrystal of pyridine–formic acid. For the 1:4 mixture, a new polymorph has been identified at a pressure of 14.2 kbar with a distinctly different structure and bonding pattern to that of the previously reported low temperature form.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Date accepted:31 May 2016
Date deposited:30 June 2016
Date of first online publication:01 June 2016
Date first made open access:01 June 2017

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