Sticking and sliding of lipid bilayers on deformable substrates

Stubbington, Liam; Arroyo, Marino; Staykova, Margarita

doi:10.1039/c6sm00786d

Sticking and sliding of lipid bilayers on deformable substrates

Stubbington, Liam; Arroyo, Marino; Staykova, Margarita

Authors

Liam Stubbington

Marino Arroyo

Dr Margarita Staykova margarita.staykova@durham.ac.uk
Associate Professor

Abstract

We examine here the properties of lipid bilayers coupled to deformable substrates. We show that by changing the extent of the substrate hydrophilicity, we can control the membrane–substrate coupling and the response of the bilayer to strain deformation. Our results demonstrate that lipid bilayers coupled to flexible substrates can easily accommodate large strains, form stable protrusions and open reversibly pores. These properties, which differ significantly from those of free standing membranes, can extend the applications of the current lipid technologies. Moreover, such systems better capture the mechanical architecture of the cell interface and can provide insights into the capacity of cells to reshape and respond to mechanical perturbations.

Citation

Stubbington, L., Arroyo, M., & Staykova, M. (2016). Sticking and sliding of lipid bilayers on deformable substrates. Soft Matter, 13, 181-186. https://doi.org/10.1039/c6sm00786d

Journal Article Type	Article
Acceptance Date	Jun 10, 2016
Online Publication Date	Jun 13, 2016
Publication Date	Jun 13, 2016
Deposit Date	Jun 29, 2016
Publicly Available Date	Jul 4, 2016
Journal	Soft Matter
Print ISSN	1744-683X
Electronic ISSN	1744-6848
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	13
Pages	181-186
DOI	https://doi.org/10.1039/c6sm00786d