Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Mallia, C.J.; Walter, G.C.; Baxendale, I.R.

doi:10.3762/bjoc.12.147

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Mallia, C.J.; Walter, G.C.; Baxendale, I.R.

Authors

C.J. Mallia

G.C. Walter

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

Citation

Mallia, C., Walter, G., & Baxendale, I. (2016). Flow carbonylation of sterically hindered ortho-substituted iodoarenes. Beilstein Journal of Organic Chemistry, 12, 1503-1511. https://doi.org/10.3762/bjoc.12.147

Journal Article Type	Article
Acceptance Date	Jun 27, 2016
Online Publication Date	Jul 19, 2016
Publication Date	Jul 19, 2016
Deposit Date	Aug 9, 2016
Publicly Available Date	Aug 9, 2016
Journal	Beilstein Journal of Organic Chemistry
Print ISSN	1860-5397
Publisher	Beilstein-Institut
Peer Reviewed	Peer Reviewed
Volume	12
Pages	1503-1511
DOI	https://doi.org/10.3762/bjoc.12.147

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© 2016 Mallia et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)