C.J. Mallia
Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant
Mallia, C.J.; Burton, P.M.; Smith, A.M.R.; Walter, G.C.; Baxendale, I.R.
Authors
Abstract
A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has been used to simplify the delivery of the oxygen accelerating the optimisation phase and allowing easy access to elevated pressures. A small exemplification library of heteroaromatic products has been prepared and the process has been shown to be robust over extended reaction times.
Citation
Mallia, C., Burton, P., Smith, A., Walter, G., & Baxendale, I. (2016). Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant. Beilstein Journal of Organic Chemistry, 12, 1598-1607. https://doi.org/10.3762/bjoc.12.156
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 13, 2016 |
Online Publication Date | Jul 26, 2016 |
Publication Date | Jul 26, 2016 |
Deposit Date | Aug 9, 2016 |
Publicly Available Date | Mar 29, 2024 |
Journal | Beilstein Journal of Organic Chemistry |
Print ISSN | 1860-5397 |
Publisher | Beilstein-Institut |
Peer Reviewed | Peer Reviewed |
Volume | 12 |
Pages | 1598-1607 |
DOI | https://doi.org/10.3762/bjoc.12.156 |
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Copyright Statement
© 2016 Mallia et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
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