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Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.

Lethbridge, N.L. and Chazot, P.L. (2016) 'Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.', Pharmacological research., 113 (Part A). pp. 245-256.

Abstract

Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 receptors (H3R) in a series of major cortical and basal ganglia structures in human DLB and Alzheimer’s (AD) post-mortem cases using the highly selective radioligand, [3H] GSK189254. In the main, the levels of H3 receptor were largely preserved in DLB cases when compared with aged-matched controls. However, we provide new evidence showing variable levels in the globus pallidus, and, moreover, raised levels of Pallidum H3 correlated with positive psychotic symptoms, in particular delusions and visual hallucinations, but not symptoms associated with depression. Furthermore, no correlation was detected for H3 receptor levels to MMSE or IUPRS symptom severity. This study suggests that H3R antagonists have scope for treating the psychotic symptomologies in DLB and other human brain disorders.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Full text:(VoR) Version of Record
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1016/j.phrs.2016.08.034
Publisher statement:© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
Date accepted:31 August 2016
Date deposited:08 September 2016
Date of first online publication:31 August 2016
Date first made open access:No date available

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