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The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient.

Forssell-Aronsson, E. and Quinlan, R.A. (2017) 'The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient.', Radiation protection dosimetry., 173 (1-3). pp. 16-20.

Abstract

Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1093/rpd/ncw328
Publisher statement:This is a pre-copyedited, author-produced version of an article accepted for publication in Radiation Protection Dosimetry following peer review. The version of record Forssell-Aronsson, E. & Quinlan, R.A. (2017). The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient. Radiation Protection Dosimetry, 173 (1-3): 16-20 is available online at: https://doi.org/10.1093/rpd/ncw328.
Date accepted:28 October 2016
Date deposited:14 November 2016
Date of first online publication:15 November 2016
Date first made open access:15 November 2017

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