Neil, E.R. and Parker, D. (2017) 'Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex.', RSC advances., 7 (8). pp. 4531-4540.
Abstract
A europium complex bearing a phenylboronic acid group has been created that binds reversibly in methanol to sialic acid and lactic acid, as signalled by changes in the Eu total emission spectrum and the induction of strong circularly polarised luminescence. An analogue lacking the boronate moiety displays no spectral response towards sialic acid. The CPL signature is distinctive for sialic acid, and differs from that observed with methyl sialate and N-acetyl glucosamine. A hypothetical binding model is promulgated, where binding of the amide carbonyl to the Eu centre occurs at the same time as the terminal diol group of the glycerol moiety chelates to the boron atom.
| Item Type: | Article |
|---|---|
| Full text: | (AM) Accepted Manuscript Available under License - Creative Commons Attribution. Download PDF (3246Kb) |
| Full text: | (VoR) Version of Record Available under License - Creative Commons Attribution. Download PDF (1026Kb) |
| Status: | Peer-reviewed |
| Publisher Web site: | https://doi.org/10.1039/C6RA26662B |
| Publisher statement: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| Date accepted: | 14 December 2016 |
| Date deposited: | 03 March 2017 |
| Date of first online publication: | 16 January 2017 |
| Date first made open access: | No date available |
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